Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region.
And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels.
DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors.
Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors.
Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1.
DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 37.0 kDa.
The protein migrates as 50-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：20ug
Source：Human Dkk-3 (R335G), His Tag (DK3-H5220) is expressed from human 293 cells (HEK293). It contains AA Ala 22 - Ile 350 (Accession # Q9UBP4-1 (R335G)).
