Decorin is also known as bone proteoglycan II, PGS2, SLRR1B, DCN, DSPG2 and PG40, is a secreted chondroitin /dermatan sulfate proteoglycan in the family of small leucine-rich proteoglycans (SLRPs).
Decorin is a small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein.
Decorin and biglycan are thought to be the result of a gene duplication.
This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly.
Decorin appears to influence fibrillogenesis, and also interacts with fibronectin, thrombospondin, the complement component C1q, epidermal growth factor receptor (EGFR) and transforming growth factor-beta (TGF-beta).
Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD).
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 38.8 kDa.
The protein migrates as 46-55 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.
仕様
容量：200ug
Source：Human Decorin, His Tag (DE1-H5223) is expressed from human 293 cells (HEK293). It contains AA Gly 17 - Lys 359 (Accession # NP_001911.1).
