C-C chemokine ligand 5 (CCL5), also known as RANTES, is a target gene of NF-kappaB, and is expressed by T lymphocytes, macrophages, platelets, synovial fibroblasts, tubular epithelium, and certain types of tumour cells.
CCL5 plays a role in recruiting a variety of leukocytes into inflammatory sites including T cells, macrophages, eosinophils, and basophils.
CCL5 activity is mediated through its binding to CCR1, CCR3, and mainly CCR5.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 34.4 kDa.
The protein migrates as 40 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：20ug
Source：Human CCL5, Fc Tag (CC5-H5251) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Ser 91 (Accession # P13501-1).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc
Exp Region：Ser 24 - Ser 91
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P13501-1
Protein ID：NP_002976.2
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
