CD28 homolog (CD28H), also called transmembrane and immunoglobulin domain containing 2 (TMIGD2) and IGPR-1,is encoded by the TMIGD2 gene.
CD28H is constitutively expressed on naive T and NK cells.
After interaction of CD28 homolog with B7 homologue,the peripheral effector and memory T cells can be activated and proliferated by Akt-dependent signalling cascade.
Plays a role in cell-cell interaction, cell migration, and angiogenesis.
Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation.
Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 40.6 kDa.
As a result of glycosylation, the protein migrates as 50-60 kDa under reducing (R) condition, and 90-116 kDa under non-reducing (NR) condition (SDS-PAGE).
仕様
容量：100ug
Source：Human CD28H, Fc Tag (CDH-H5251) is expressed from human 293 cells (HEK293). It contains AA Leu 23 - Gly 150 (Accession # AAH15655.1).
