Tumor necrosis factor ligand superfamily member 14(LIGHT) is a tumor necrosis factor (TNF) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator (HVEM) and the lymphotoxin beta receptor (LTbetaR).
LIGHT has emerged as a potent initiator of T cell co-stimulation signals effecting CTL-mediated tumor rejection, allograft rejection and graft versus host disease.
Constitutive expression of LIGHT leads to tissue destruction and autoimmune-like disease syndromes.
特徴
This protein carries a human IgG1 Fc tag at the N-terminus.
The protein has a calculated MW of 82.6 kDa.
The protein migrates as 116 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human LIGHT Protein, Fc Tag (LIT-H5269) is expressed from human 293 cells (HEK293). It contains AA Asp 74 - Val 240 (Accession # O43557-1) trimer Design.
Species Reactivity：Human
Host：HEK293
Tag：N-Fc
Exp Region：Asp 74 - Val 240
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：O43557-1
Protein ID：NP 003798.2
Endotoxin：1.0 EU per μg
Purity：90%
Buffer：50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5
