83-3842-19　Mouse CD38 Protein, His Tag 100ug　CD8-M5223-100ug

特徴

• 背景
• CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family.
• CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
• CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose.
• These reaction products are essential for the regulation of intracellular Ca2+.
• The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications.
• The CD38 protein is a marker of cell activation.
• It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism.
• CD38 has been used as a prognostic marker in leukemia.
• 特徴
• This protein carries a polyhistidine tag at the C-terminus.
• The protein has a calculated MW of 31.7 kDa.
• The protein migrates as 38-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.