Cluster of differentiation 14 (CD14), is a cell surface glycoprotein, and is a is a component of the innate immune system.
CD14 is a myelomonocytic differentiation antigen preferentially expressed on monocytes, macrophages, and activated granulocytes.
CD14 exists in two forms.
Either it is anchored into the membrane by a glycosylphosphatidylinositol tail (mCD14) or it appears in a soluble form (sCD14).
Soluble CD14 either appears after shedding of mCD14 (48 kDa) or is directly secreted from intracellular vesicles (56 kDa).
CD14 acts as a co-receptor (along with the Toll-like receptor TLR 4 and MD-2) for the detection of bacterial lipopolysaccharide (LPS).
CD14 can bind LPS only in the presence of lipopolysaccharide-binding protein (LBP).
CD14 has been proposed to be involved in various biological processes, including transportation of other lipids, cell-cell interaction during different immune responses, as well as recognition of apoptotic cells.
Although LPS is considered its main ligand, CD14 also recognizes other pathogen-associated molecular patterns.
CD14+ cells are monocytes that can differentiate into a host of different cells.
CD14 has been shown to interact with Lipopolysaccharide-binding protein.
特徴
This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag).
The protein has a calculated MW of 38.6 kDa.
The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：200ug
Source：Biotinylated Human CD14, His,Avitag (CD4-H8228) is expressed from human 293 cells (HEK293). It contains AA Thr 20 - Met 344 (Accession # P08571-1 ).
