83-3841-64　Human CD14 Protein, Fc Tag （MALS verified） 1mg　CD4-H5252-1mg

特徴

• 背景
• Cluster of differentiation 14 (CD14), is a cell surface glycoprotein, and is a is a component of the innate immune system.
• CD14 is a myelomonocytic differentiation antigen preferentially expressed on monocytes, macrophages, and activated granulocytes.
• CD14 exists in two forms.
• Either it is anchored into the membrane by a glycosylphosphatidylinositol tail (mCD14) or it appears in a soluble form (sCD14).
• Soluble CD14 either appears after shedding of mCD14 (48 kDa) or is directly secreted from intracellular vesicles (56 kDa).
• CD14 acts as a co-receptor (along with the Toll-like receptor TLR 4 and MD-2) for the detection of bacterial lipopolysaccharide (LPS).
• CD14 can bind LPS only in the presence of lipopolysaccharide-binding protein (LBP).
• CD14 has been proposed to be involved in various biological processes, including transportation of other lipids, cell-cell interaction during different immune responses, as well as recognition of apoptotic cells.
• Although LPS is considered its main ligand, CD14 also recognizes other pathogen-associated molecular patterns.
• CD14+ cells are monocytes that can differentiate into a host of different cells.
• CD14 has been shown to interact with Lipopolysaccharide-binding protein.
• 特徴
• This protein carries a human IgG1 Fc tag at the C-terminus.
• The protein has a calculated MW of 62.2 kDa.
• The protein migrates as 75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.