83-3841-48　Rhesus macaque CD4 Protein, Fc Tag （MALS verified） 1mg　CD4-C5256-1mg

特徴

• 背景
• T-cell surface glycoprotein CD4 is also known as T-cell surface antigen T4/Leu-3.
• CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain.
• CD4 is accessory protein for MHC class-II antigen/T-cell receptor interaction.
• CD4 induces the aggregation of lipid rafts.
• CD4 is a primary receptor used by HIV-1 to gain entry into host T cells.
• HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors.
• Therefore, medical professionals refer to the CD4 count to decide when to begin treatment for HIV-infected patients.
• 特徴
• This protein carries a human IgG1 Fc tag at the C-terminus.
• The protein has a calculated MW of 67.0 kDa.
• The protein migrates as 67-85 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.