83-3840-72 Human CLEC12A / MICL / CLL-1 Protein, Fc Tag （MALS verified） 50ug CLA-H5266-50ug
特徴
- 背景
- CLEC12A (C-type lectin domain family 12 member A) is also known as CLL1, DCAL2, MICL.
- Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death.
- Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.
- Evidence of distinct disease propagating stem cells in myelodysplastic syndrome (MDS) has emerged in recent years.
- The role of CLEC12A in MDS, however, remains to be elucidated.
- Furthermore, CLEC12A has been proposed as a promising marker of leukaemic stem cells in AML.
- 特徴
- This protein carries a human IgG1 Fc tag at the N-terminus.
- The protein has a calculated MW of 50.2 kDa.
- The protein migrates as 55-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
- 容量：50ug
- Source：Human CLEC12A, Fc Tag (CLA-H5266) is expressed from human 293 cells (HEK293). It contains AA His 65 - Ala 265 (Accession # Q5QGZ9-2).
- Species Reactivity：Human
- Host：HEK293
- Tag：N-Fc
- Exp Region：His 65 - Ala 265
- Format：Powder
- Conjugate：Unconjugated
- Swiss-Prot：Q5QGZ9-2
- Protein ID：NP_612210.4
- Endotoxin：1.0 EU per μg
- Purity：95%
- Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
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