Probetacellulin can be cleaved into the Betacellulin (BTC) that is a single-pass type I membrane protein containing 1 EGF-like domain.
Predominantly expressed in pancreas and small intestine,Betacellulin (BTC) is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events.
As a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells, Betacellulin (BTC) is also the growth factor that binds to EGFR, ERBB4 and other EGF receptor family members.
Betacellulin (BTC) was originally identified as a growth-promoting factor in mouse pancreatic β-cell carcinoma cell line and has since been identified in humans.
The amino acid sequence of mature mBTC is 82.5%, identical with that of human BTC (hBTC), and both exhibit significant overall similarity with other members of the EGF family.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 35.8 kDa.
The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human Betacellulin, Fc Tag (BEN-H525x) is expressed from human 293 cells (HEK293). It contains AA Asp 32 - Tyr 111 (Accession # AAH11618).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc
Exp Region：Asp 32 - Tyr 111
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P35070
Protein ID：AAH11618
Endotoxin：1.0 EU per μg
Purity：92%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
