Poliovirus receptor-related protein 1 (PVRL1) is also known as Herpes virus entry mediator C (HveC), Herpesvirus Ig-like receptor (HIgR), Nectin-1, CD antigen CD111, PVRL1 / Nectin-1 / CD111 belongs to the nectin family.
PVRL1 / Nectin-1 is a membrane protein with three extracellular immunoglobulin domains, a single transmembrane helix and a cytoplasmic tail.
The protein can mediate Ca2+-independent cellular adhesion further characterizing it as IgSF cell adhesion molecule (IgSF CAM).
PVRL1 is adhesion molecule found in a wide range of tissues.
PVRL1 / Nectin-1 promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers.
Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 60.4 kDa.
The protein migrates as 66-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human Nectin-1, Fc Tag (PV1-H5253) is expressed from human 293 cells (HEK293). It contains AA Gln 31 - Thr 334 (Accession # Q15223-1).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc
Exp Region：Gln 31 - Thr 334
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：Q15223-1
Protein ID：NP_002846.3
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
