AXL Receptor Tyrosine Kinase is also known as Tyrosine-protein kinase receptor UFO, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily.
AXL contains two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain.
AXL is highly expressed in metastatic colon tumors.
AXL is activated by GAS6-binding and subsequent autophosphorylation.
AXL is involved in signal transduction from the extracellular matrix into the cytoplasm by binding growth factors, and thus implicated in the stimulation of cell proliferation.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 72.6 kDa.
The protein migrates as 95-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human Axl, Fc Tag (AXL-H5253) is expressed from human 293 cells (HEK293). It contains AA Ala 26 - Trp 451 (Accession # P30530-1).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc
Exp Region：Ala 26 - Trp 451
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P30530-1
Protein ID：NP_068713.2
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：50 mM Tris, 100 mM Glycine, 150 mM NaCl, 25 mM Arginine, pH7.5
