83-3840-13　Human FGF acidic Protein, Tag Free 1mg　AFF-H4116-1mg

特徴

• 背景
• Heparin-binding growth factor 1 is a protein that in humans is encoded by the FGF1 gene.
• The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family.
• FGF acidic is a potent growth factor for fibroblasts and endothelial cells.
• FGF acidic is involved in wound repair, angiogenesis, and development.
• FGF acidic is secreted from cells via an endoplasmic reticulum/Golgi independent mechanism.
• The ability of FGF acidic to bind to heparin sulfate is required for its ability to interact with FGF receptors and induce signaling.
• There are four distinct FGF receptors and each has multiple splice variants.
• FGF acidic binds with high affinity to many, but not all, FGFRs.
• Signaling cascades activated through FGF basic binding to FGFR include the ras-raf-MAPK, PLCγ/PKC, and PI3K/Akt pathways.
• 特徴
• This protein carries no "tag".
• The protein has a calculated MW of 16.0 kDa.
• The protein migrates as 16 kDa under reducing (R) condition (SDS-PAGE).