83-3839-52 Human VSIG3 Protein, Fc Tag 100ug VS3-H5258-100ug
特徴
- 背景
- VSIG3, also known as IGSF11, BT-IgSF, and CLMP, is a homophilic adhesion molecule that preferentially expressed in the brain.
- The function of VSIG3 is to stimulate cell growth through homophilic interactions.
- In clinical, the VSIG3 has been reported to as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas.
- In addition, VSIG-3 is also a ligand of B7 family member VISTA/PD-1H and inhibits human T-cell functions through a novel VSIG-3/VISTA pathway.
- VSIG-3/VISTA co-inhibitory pathway may provide new strategies for the treatment of human cancers and autoimmune disorders.
- 特徴
- This protein carries a human IgG1 Fc tag at the C-terminus.
- The protein has a calculated MW of 49.7 kDa.
- The protein migrates as 60-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
- 容量：100ug
- Source：Human VSIG3, Fc Tag (VS3-H5258) is expressed from human 293 cells (HEK293). It contains AA Leu 23 - Gly 241 (Accession # Q5DX21-1).
- Species Reactivity：Human
- Host：HEK293
- Tag：C-Fc
- Exp Region：Leu 23 - Gly 241
- Format：Powder
- Conjugate：Unconjugated
- Swiss-Prot：Q5DX21-1
- Protein ID：NP_001015887.1
- Endotoxin：1.0 EU per μg
- Purity：95%
- Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
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