Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family.
The CD112R gene encodes a putative single transmembrane protein, which is composed of a single extracellular IgV domain, one transmembrane domain, and a long intracellular domain.
Notably, the intracellular domain of phatases.
The extracellular domain sequence of human and mouse CD112R have 65.3% similarity.
CD112R may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 40.6 kDa.
The protein migrates as 48-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Mouse PVRIG, Fc Tag (PVG-M5257) is expressed from human 293 cells (HEK293). It contains AA Ser 35 - Asp 165 (Accession # A0A1B0GS01-1).
Species Reactivity：Mouse
Host：HEK293
Tag：C-Fc
Exp Region：Ser 35 - Asp 165
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：A0A1B0GS01-1
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
