Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family.
The CD112R gene encodes a putative single transmembrane protein, which is composed of a single extracellular IgV domain, one transmembrane domain, and a long intracellular domain.
Notably, the intracellular domain of phatases.
The extracellular domain sequence of human and mouse CD112R have 65.3% similarity.
CD112R may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 40.1 kDa.
The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Cynomolgus PVRIG, Fc Tag (PVG-C5259) is expressed from human 293 cells (HEK293). It contains AA Thr 41 - Asp 171 (Accession # A0A2K5WVV8-1).
Species Reactivity：Cynomolgus
Host：HEK293
Tag：C-Fc
Exp Region：Thr 41 - Asp 171
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：A0A2K5WVV8-1
Protein ID：XP_005549281.1
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
