Insulin receptor (INSR) is also known as CD antigen CD220, which can be cleaved into the following 2 chains: Insulin receptor subunit alpha and Insulin receptor subunit beta.
INSR is a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds.
The alpha chains carry the insulin-binding regions, while the beta chains carry the kinase domain.
Forms a hybrid receptor with IGF1R, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R.
In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII).
Isoform Short of INSR has a higher affinity for IGFII binding.
When present in a hybrid receptor with IGF1R, INSR binds IGF1.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The mature form of Insulin R a disulfide-linked heterotetramer composed of 2 alpha and 2 beta chains.
Each α and β chain (partial fragment) has a calculated MW of 83.6 kDa and 22.8 kDa.
The protein migrates as 120-130 kDa and 35-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human Insulin R (28-944), His Tag (INR-H52Ha) is expressed from human 293 cells (HEK293). It contains AA His 28 - Lys 944 (Accession # P06213-2).
