Fibroblast Growth Factor 10 (FGF 10) is an evolutionary conserved secreted growth factor mediating mostly mesenchymal to epithelial signaling.
FGF 10 belongs to the FGF 7 subfamily and shares similar biochemical and amino acid sequences with its constituent members (FGF3, FGF 7 and FGF 22).
As a paracrine FGF, FGF 10 elicits its biological responses by activating the fibroblast growth factor receptor 2b (FGF R 2b), is crucial for governing proximal distal outgrowth as well as patterning and acts upstream of the known apical ectodermal ridge (AER) marker FGF 8.
FGF10 is also implicated in pancreatic cancer, and that overexpression of FGFR2b is associated with metastatic invasion.
特徴
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 21.2 kDa.
The protein migrates as 27 kDa under reducing (R) condition (SDS-PAGE).
仕様
容量：1mg
Source：Human FGF-10 Protein, His Tag, premium grade (FG0-H5145) is expressed from E. coli cells. It contains AA Gln 38 - Ser 208 (Accession # O15520-1).
Species Reactivity：Human
Host：E. coli
Tag：N-10×His
Exp Region：Gln 38 - Ser 208
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：O15520-1
Endotoxin：0.1 EU per μg
Purity：95%
Buffer：20 mM MOPS, 200 mM NaCl, 100 mM Na2SO4, 1mM EDTA, 1mM DTT, pH7.0
