GP protein contains 160-kDa envelope-attached glycoprotein (GP) and a 110 kDa secreted glycoprotein (sGP).
GP is a class I fusion protein which assembles as trimers on viral surface and plays an important role in virus entry and attachment.
Mature GP is a disulfide-linked heterodimer formed by two subunits, GP1 and GP2, which are generated from the proteolytical process of GP precursor (pre-GP) by cellular furin during virus assembly .
GP1 is responsible for binding to the receptor(s) on target cells.
Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell.
GP2 acts as a class I viral fusion protein.
GP1,2 mediates endothelial cell activation and decreases endothelial barrier function.
sGP seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 34.3 kDa.
The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE).
仕様
容量：1mg
Source：Ebolavirus BDBV (subtype Bundibugyo, strain Uganda 2007) sGP Protein, His Tag (BEP-V5220) is expressed from human 293 cells (HEK293). It contains AA Ile 33 - Arg 324 (Accession # B8XCN1).
