Tumor necrosis factor ligand superfamily member 14(LIGHT) is a tumor necrosis factor (TNF) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator (HVEM) and the lymphotoxin beta receptor (LTbetaR).
LIGHT has emerged as a potent initiator of T cell co-stimulation signals effecting CTL-mediated tumor rejection, allograft rejection and graft versus host disease.
Constitutive expression of LIGHT leads to tissue destruction and autoimmune-like disease syndromes.
特徴
This protein carries a mouse IgG2a Fc tag at the N-terminus.
The protein has a calculated MW of 45.1 kDa.
The protein migrates as 50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human LIGHT Protein, Mouse IgG2a Fc Tag (LIT-H5256) is expressed from human 293 cells (HEK293). It contains AA Asp 74 - Val 240 (Accession # O43557-1).
Species Reactivity：Human
Host：HEK293
Tag：N-mFc(mIgG2a)
Exp Region：Asp 74 - Val 240
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：O43557-1
Protein ID：NP 003798.2
Endotoxin：0.1 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
