Claudins constitute integral membrane proteins responsible for solute and electrolyte permeability of the tight junction that serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets.
Tight junctions also play a critical role in maintaining cell polarity and signal transductions.
Claudin-9 creates charge specific channels in the paracellular space, plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity, is required to preserve sensory cells in the hearing organ because claudin-9-defective tight junctions fail to shield the basolateral side of hair cells from the K+-rich endolymph.
Its ion barrier function is essential in the cochlea, but appears to be dispensable in other organs.
Is one of the entry cofactors for hepatitis C virus; it enables HCV entry into target cells just as efficiently as CLDN1.
特徴
This protein .
仕様
容量：100ug
Source：Human Claudin-9 Full Length Protein-VLP (CL9-H52P5) is expressed from human 293 cells (HEK293). It contains AA Met 1 -Val 217 (Accession # O95484-1).
