Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells.
Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells.
CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation.
CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses.
CD70 induces proliferation and IFNγ production, on NK cells.
特徴
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 18.6 kDa.
The protein migrates as 27-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Mouse CD27 Ligand Protein, His Tag (CDL-M5245) is expressed from human 293 cells (HEK293). It contains AA Gln 47 - Pro 195 (Accession # O55237-1).
