Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily.
TNFRSF17 contains one TNFR-Cys repeat.
TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes.
TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL.
TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity.
TNFRSF17 can activate NF-kappa-B and JNK.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 32.1 kDa.
The protein migrates as 36 kDa under reducing (R) condition (SDS-PAGE) due to O-linked glycosylation which has been verified by O-Glycosidase and Neuraminidase digestion.
仕様
容量：100ug
Source：Mouse BCMA, Fc Tag (BCA-M5258) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Thr 49 (Accession # O88472-1).
Species Reactivity：Mouse
Host：HEK293
Tag：C-Fc
Exp Region：Met 1 - Thr 49
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：O88472-1
Protein ID：NP_035738.1
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
