Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21.
Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity.
Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies.
Tau-441 is known as "2N4R," "Isoform Tau-F," "Tau-4" or "Tau 441", which consisting of 441 amino acid.
Tau-441 is a potential therapeutic target for pathogenesis.
特徴
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 13.5 kDa.
The protein migrates as 16 kDa under reducing (R) condition (SDS-PAGE).
仕様
容量：100ug
Source：Human Tau-441 (273-380), His Tag (TAU-H51H5) is expressed from E. coli cells. It contains AA Gly 273 - Glu 380 (Accession # P10636-8).
Species Reactivity：Human
Host：E. coli
Tag：N-10×His
Exp Region：Gly 273 - Glu 380
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P10636-8
Protein ID：NP_005901.2
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：50 mM Tris, 150 mM NaCl, 1 mM TCEP, 1 mM EDTA, pH7.5
