Myeloid cell surface antigen CD33 is also known as SIGLEC3, Siglecs (sialic acid binding Iglike lectins) and GP67, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family.
Human CD33 / Siglec-3 cDNA encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-terminal Ig-like V-type domain, one Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail.
CD33 / Siglec-3 usually considered myeloid-specific, but it can also be found on some lymphoid cells.
In the immune response, CD33 / Siglec-3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
CD33 / Siglec-3 induces apoptosis in acute myeloid leukemia.
特徴
This protein carries a llama IgG2b Fc tag at the C-terminus.
The protein has a calculated MW of 37.8 kDa.
The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human Siglec-3 (140-232), Llama IgG2b Fc Tag (CD3-H5258) is expressed from human 293 cells (HEK293). It contains AA Asp 140 - Thr 232 (Accession # P20138-1).
Species Reactivity：Human
Host：HEK293
Tag：C-LlamaFc(LlamaIgG2b)
Exp Region：Asp 140 - Thr 232
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P20138-1
Protein ID：AAH28152.1
Endotoxin：0.01 EU per μg
Purity：95%
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
