The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands.
The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4).
Mutations affecting EGFR expression or activity could result in cancer.The type III EGF deletion mutant receptor (EGFRvIII) is the most common mutation and was first identified in primary human glioblastoma tumors.
This tumor-specific antigen is ligand-independent, contains a constitutively active tyrosine kinase domain, and has been shown to be present in a number of human malignancies.
EGFRvIII has been selected as a target for CAR-modified T-cell studies in recent years.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 42.4 kDa.
仕様
容量：25tests
Source：APC-Labeled Human EGFRvIII, His Tag (EGI-HA2H8) is produced via conjugation of APC to Human EGFRvIII, His Tag with a new generation site-specific technology under optimal conditions with a proprietary technology. Human EGFRvIII, His Tag is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Ser 378 (Accession # NP_001333870.1).
