Podoplanin (PDPN) is a type I transmembrane mucin-like glycoprotein expressed in the lymphatic endothelium.
It is overexpressed in several solid tumors, such as squamous cell carcinoma, malignant mesothelioma, Kaposi sarcoma, angiosarcoma, testicular seminoma, and brain tumors.
PDPN expression is associated with malignant progression, epithelial–mesenchymal transition, and metastasis.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 37.6 kDa.
The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human Podoplanin, Fc Tag (PON-H5254) is expressed from human 293 cells (HEK293). It contains AA Ala 23 - Leu 131 (Accession # Q86YL7-1).
