Podoplanin (PDPN) is a type I transmembrane mucin-like glycoprotein expressed in the lymphatic endothelium.
It is overexpressed in several solid tumors, such as squamous cell carcinoma, malignant mesothelioma, Kaposi sarcoma, angiosarcoma, testicular seminoma, and brain tumors.
PDPN expression is associated with malignant progression, epithelial–mesenchymal transition, and metastasis.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 13.0 kDa.
The protein migrates as 19-21 kDa and 30-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human Podoplanin, His Tag (PON-H52H3) is expressed from human 293 cells (HEK293). It contains AA Ala 23 - Leu 131 (Accession # Q86YL7-1).
