TDP-43, the transactive response (TAR)-DNA binding Protein with a molecular weight of 43 KDa is encoded by TARDBP gene that located at the chromosome 1.
It is a RNA/DNA binding protein that structurally resembles a typical hnRNP protein family member.
involved in transcriptional regulation and RNA processing.
It is linked to sporadic and familial amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
TDP-43 is predominantly nuclear, but it translocates to the cytoplasm under pathological conditions.
Cytoplasmic accumulation, phosphorylation, ubiquitination and truncation of TDP-43 are the main hallmarks of TDP-43 proteinopathies.
特徴
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 46.8 kDa.
The protein migrates as 54-56 kDa under reducing (R) condition (SDS-PAGE).
仕様
容量：25ug
Source：Human TDP-43, His Tag (TD3-H5145) is expressed from E.coli cells. It contains AA Met 1 - Met 414 (Accession # Q13148-1).
Species Reactivity：Human
Host：E. coli
Tag：N-10×His
Exp Region：Met 1 - Met 414
Format：Liquid
Conjugate：Unconjugated
Swiss-Prot：Q13148-1
Endotoxin：1.0 EU per μg
Purity：90%
Buffer：50 mM HEPES, 500 mM NaCl, 0.4 M Arginine, pH8.0
