Neuropilin-1 (Npn-1, previously known as neuropilin) and Neuropilin-2 (previously known as Npn-1-related molecule) are type I transmembrane proteins that bind distinct members of the class III secreted semaphorin subfamily that are implicated in repulsive axon guidance.
Neuropilin extracellular domains contain two CUB (complement-binding) domains, two domains with homology to coagulation factors V and VIII, and a MAM (meprin) domain.
In the absence of ligands, neuropilins can form homo- and hetero-oligomers via their MAM domains.
Expression in developing neurons of the central and peripheral nervous systems is somewhat overlapping but distinct.
Npn-1 and Npn-2 are also receptors for VEGF165 on endothelial and tumor cells.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 97.0 kDa.
The protein migrates as 105-125 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human Neuropilin-2, His Tag (NR2-H52H3) is expressed from human 293 cells (HEK293). It contains AA Arg 21 - Pro 864 (Accession # O60462-1).
