The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the CXC chemokine receptor family.
This family also includes CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, and CXCR7.
This gene, which maps to the chemokine receptor gene cluster, is expressed in several T lymphocyte subsets and bone marrow stromal cells.
The encoded protein and its exclusive ligand, chemokine ligand 16 (CCL16), are part of a signalling pathway that regulates T lymphocyte migration to various peripheral tissues (the liver, spleen red pulp, intestine, lungs, and skin) and promotes cell-cell interaction with dendritic cells and fibroblastic reticular cells.
CXCR6/CCL16 also controls the localization of resident memory T lymphocytes to different compartments of the lung and maintains airway resident memory T lymphocytes, which are an important first line of defense against respiratory pathogens.
The encoded protein serves as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 45.7 kDa.
The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：50ug
Source：Human CXCL16, Fc Tag (CX6-H5254) is expressed from human 293 cells (HEK293). It contains AA Asn 30 - Thr 205 (Accession # Q9H2A7-1).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc
Exp Region：Asn 30 - Thr 205
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：Q9H2A7-1
Endotoxin：1.0 EU per μg
Purity：90%
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
