BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), is a membrane protein of the TNF receptor superfamily which recognizes BAFF.
B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population.
Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE).
Also, some SLE patients have increased levels of BAFF in serum.
Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag).
The protein has a calculated MW of 35.1 kDa.
The protein migrates as 45-60 kDa under reducing (R) condition, and 90-116 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
仕様
容量：200ug
Source：Biotinylated Mouse BAFFR, Fc,Avitag (BAR-M82F0) is expressed from human 293 cells (HEK293). It contains AA Ser 10 - Ala 71 (Accession # NP_082351).
Species Reactivity：Mouse
Host：HEK293
Tag：C-Fc & C-Avi
Exp Region：Ser 10 - Ala 71
Format：Powder
Conjugate：Biotin-labeled
Swiss-Prot：Q9D8D0
Protein ID：NP_082351
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
