B7 homolog 3 (B7-H3), a member of the immunoglobulin superfamily, is also known CD276, which contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domains.
B7-H3 may participate in the regulation of T-cell-mediated immune response.
B7-H3 also plays a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells.
Furthermore, B7-H3 is involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces.
It could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 50.1 kDa.
The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Mouse B7-H3 (2Ig) Protein, Fc Tag (B73-M5255) is expressed from human 293 cells (HEK293). It contains AA Val 29 - Phe 244 (Accession # NP_598744).
Species Reactivity：Mouse
Host：HEK293
Tag：C-Fc
Exp Region：Val 29 - Phe 244
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：Q8VE98
Protein ID：NP_598744
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
