This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16.
Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes.
The CC cytokines are proteins characterized by two adjacent cysteines.
The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes.
It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes.
The product of this gene binds to chemokine receptor CCR4.
This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 34.5 kDa.
The protein migrates as 35-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human CCL22, Fc Tag (CC2-H5257) is expressed from human 293 cells (HEK293). It contains AA Gly 25 - Gln 93 (Accession # O00626-1).
