Human CD30 is also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker.
TNFRSF-8 is expressed by activated, but not by resting, T and B cells.
Also, CD30 is expressed on classical Hodgkin Lymphoma cells together with CD15.
CD30 is the receptor for TNFSF8/CD30L.
CD30 can interact with TRAF2 and TRAF5, and mediate the signal transduction that leads to the activation of NF-kappa-B.
TNFRSF8 may play a role in the regulation of cellular growth and transformation of activated lymphoblasts.
TNFRSF8 is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag).
The protein has a calculated MW of 66.6 kDa.
The protein migrates as 80-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：200ug
Source：Biotinylated Human CD30, Fc,Avitag (CD0-H82F4) is expressed from human 293 cells (HEK293). It contains AA Phe 19 - Lys 379 (Accession # NP_001234.2).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc & C-Avi
Exp Region：Phe 19 - Lys 379
Format：Powder
Conjugate：Biotin-labeled
Protein ID：NP_001234.2
Endotoxin：1.0 EU per μg
Purity：90%
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
