G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis.
Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis.
Plays an important role in mediating the responses to fasting.
Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.
Promotes activation of adenylate cyclase.
Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 39.5 kDa.
The protein migrates as 50-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Mouse GCGR, Fc Tag (GCR-M5254) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Lys 137 (Accession # Q61606-1).
Species Reactivity：Mouse
Host：HEK293
Tag：C-Fc
Exp Region：Ala 27 - Lys 137
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：Q61606-1
Protein ID：NP_032127.2
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
