83-3831-01　Rabbit CD47 Protein, Fc Tag 1mg　CD7-R5257-1mg

特徴

• 背景
• Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6.
• CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain.
• CD47 is very broadly distributed on normal adult tissues.
• CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity.
• CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
• CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.
• 特徴
• This protein carries a human IgG1 Fc tag at the C-terminus.
• The protein has a calculated MW of 40.4 kDa.
• The protein migrates as 48-58 kDa under reducing (R) condition, and 85-110 kDa and 160-220 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.