B7-1 and B7-2, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T and Bcell responses.
Although both CTLA4 and CD28 can bind to the same ligands, CTLA4 binds to B71 and B72 with a 20 100 fold higher affinity than CD28 and is involved in the downregulation of the immune response.B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells.
It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation).
CD80 works in tandem with CD86 to prime T cells.
CD80 plays a role in induction of innate immune responses by activating NF-κB-signaling pathway in macrophages.
CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
特徴
This protein carries a mouse IgG2a Fc tag at the C-terminus.
The protein has a calculated MW of 50.9 kDa.
The protein migrates as 65-85 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human B7-1, Mouse IgG2a Fc Tag (B71-H52A4) is expressed from human 293 cells (HEK293). It contains AA Val 35 - Asn 242 (Accession # P33681-1).
Species Reactivity：Human
Host：HEK293
Tag：C-mFc(mIgG2a)
Exp Region：Val 35 - Asn 242
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P33681-1
Protein ID：NP 005182.1
Endotoxin：0.1 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
