Stathmin (STMN1), a member of the stathmin family, is also known as Leukemia-associated phosphoprotein p18, Oncoprotein 18 (Op18), Phosphoprotein p19 (pp19), Protein Pr22 and pp17, which contains one SLD (stathmin-like) domain.
The function of STMN1 as an important regulatory protein of microtubule dynamics has been well-characterized.
Stathmin (STMN1) interacts with two molecules of dimeric α,β-tubulin to form a tight ternary complex called the T2S complex.One mole of STMN1 binds to two moles of tubulin dimers through the stathmin-like domain (SLD).When STMN1 sequesters tubulin into the T2S complex, tubulin becomes non-polymerizable.
Without tubulin polymerization, there is no microtubule assembly.STMN1 also promotes microtubule disassembly by acting directly on the microtubule ends.
特徴
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 18.1 kDa.
The protein migrates as 18 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).
仕様
容量：100ug
Source：Human Stathmin 1, His Tag (ST1-H5149) is expressed from E. coli cells. It contains AA Ala 2 - Asp 149 (Accession # NP_981946).
