Diablo homolog, mitochondrial (DIABLO) is also known as direct IAP-binding protein with low pI and second mitochondria-derived activator of caspase (SMAC), which can interact with BIRC2/c-IAP1, BIRC3/c-IAP2, XIAP/BIRC4, BIRC6/bruce and BIRC7/livin.
Acting by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP),DIABLO can also promote apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway.
Also, DIABLO inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases.
Furthermore, DIABLO is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 21.7 kDa.
The protein migrates as 22 kDa under reducing (R) condition (SDS-PAGE).
仕様
容量：1mg
Source：Human SMAC, His Tag (DIO-H5129) is expressed from E. coli cells. It contains AA Ala 56 - Asp 239 (Accession # NP_063940).
