SERPINE2 is also known as Glia-derived nexin (GDN), Peptidase inhibitor 7 (PI7), Protease nexin 1(PN1).
SERPINE2 is a secreted glycoprotein which belongs to the serpin family.
SerpinE1 is the primary physiological inhibitor of the two plasminogen activators urokinase (uPA) and tissue plasminogen activator (tPA).
PAI-1 / GDN is also implicated in adipose tissue development.
It suggests that PAI-1 inhibitors serve in the control of atherothrombosis.
Defects in Serpin E1 / PN1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency) which is characterized by abnormal bleeding due to SerpinE1 defect in the plasma.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 42.8 kDa.
The protein migrates as 48-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：25ug
Source：Human Serpin E2, His Tag (SE2-H5225) is expressed from human 293 cells (HEK293). It contains AA Ser 20 - Pro 397 (Accession # P07093-2).
