NKG2D is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors, also known as KLRK1, CD314, D12S2489E, KLR and killer cell lectin like receptor K1.
NKG2D itself forms a homodimer whose ectodomains serve for ligand binding.
NKG2D is a major recognition receptor for the detection and elimination of transformed and infected cells as its ligands are induced during cellular stress, either as a result of infection or genomic stress such as in cancer.
In NK cells, NKG2D serves as an activating receptor, which itself is able to trigger cytotoxicity.
The function of NKG2D on CD8+ T cells is to send co-stimulatory signals to activate them.
特徴
This protein carries a human IgG1 Fc tag at the N-terminus.
The protein has a calculated MW of 43.1 kDa.
The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human NKG2D, Fc Tag (HPLC-verified) (NKD-H5265) is expressed from human 293 cells (HEK293). It contains AA Ile 73 - Val 216 (Accession # P26718-1).
Species Reactivity：Human
Host：HEK293
Tag：N-Fc
Exp Region：Ile 73 - Val 216
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P26718-1
Protein ID：NP_031386.2 (T72A)
Endotoxin：1.0 EU per μg
Purity：90%
Buffer：50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5
