Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction.
MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites.
Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization.
Probably plays a role in maintaining homeostasis on mucosal surfaces.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 60.2 kDa.
The protein migrates as 70 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.
仕様
容量：100ug
Source：Human Mucin-1 (24-380), Fc Tag (MU1-H5254) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Ser 380 (Accession # P15941-1).
