APRIL(a proliferation-inducing ligand) is also known as Tumor necrosis factor ligand superfamily member 13, TALL-2, TRDL-1, CD256, TNFFSF 13, cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA.
APRIL is a cytokine of the tumor necrosis factor family associated mainly with hematologic malignancies.
The closely related TNF family ligands B cell activation factor (BAFF) and a proliferation-inducing ligand (APRIL) serve in the generation and maintenance of mature B-lymphocytes.
Both BAFF and APRIL assemble as homotrimers that bind and activate several receptors that they partially share.
BAFF-APRIL heteromers of different stoichiometries have distinct receptor-binding properties and activities.
In addition, expression of APRIL was regulated by miR-145 in GC cells.
特徴
This protein carries a polyhistidine tag at the N-terminus, followed by a flag tag.
The protein has a calculated MW of 50.4 kDa.
The protein migrates as 55-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Cynomolgus APRIL, His,Flag Tag (APL-C52D2) is expressed from human 293 cells (HEK293). It contains AA Gln 111 - Leu 250 (Accession # XP_005582818.1) trimer Design.
