Transmembrane glycoprotein NMB (GPNMB) is also known as Transmembrane glycoprotein HGFIN, DC-HIL and Osteoactivin (OA), which belongs to the PMEL/NMB family.
GPNMB contains one PKD domain.
GPNMB is a transmembrane glycoprotein that is up-regulated in various cancer cells, including in glioblastoma multiforme and is expressed in many melanoma cells, as well as in tissue macrophages.
GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function.
GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 53.4 kDa.
The protein migrates as 85-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human Osteoactivin, His Tag (GPB-H5229) is expressed from human 293 cells (HEK293). It contains AA Ala 22 - Pro 486 (Accession # AAH32783).
