Natural cytotoxicity triggering receptor 3 (NCR3) is also known as Activating natural killer receptor p30, Natural killer cell p30-related protein (NK-p30), CD antigen CD337, 1C7, LY117.
NCR3 /CD337 /NKp30 belongs to the natural cytotoxicity receptor (NCR) family.
NCR3 /NKp30 contains one Ig-like (immunoglobulin-like) domain.
NCR3 /NKp30 is selectively expressed by all resting and activated NK cells and weakly expressed in spleen.
NCR3 is homodimer in the unliganted form.
NCR3 interacts with CD3Z.
NCR3 interacts with and is activated by binding to NCR3LG1 or BAG6.
Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 39.5 kDa.
The protein migrates as 50-58 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human NKp30, Fc Tag (NC3-H5259) is expressed from human 293 cells (HEK293). It contains AA Leu 19 - Gly 135 (Accession # AAH52582).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc
Exp Region：Leu 19 - Gly 135
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：O14931
Protein ID：AAH52582
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5
