Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the immunoglobulin superfamily which forms part of adherens junctions.
Nectins are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559).
Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton.
The nectin-afadin system organizes adherens junctions cooperatively with the cadherin system in epithelial cells.
PVRL3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions.
Furthermore, PVRL3 induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 64.3 kDa.
The protein migrates as 80-95 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human Nectin-3, Fc Tag (PV3-H5255) is expressed from human 293 cells (HEK293). It contains AA Gly 58 - Asp 400 (Accession # Q9NQS3).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc
Exp Region：Gly 58 - Asp 400
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：NP_056295.1
Protein ID：Q9NQS3
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
