LRRC4 (Leu-rich repeat/LRR-containing glycoprotein 4), LRRC4B and LRRC4C are post-synaptic adhesion molecules of the LRR protein family that induce excitatory synapse formation.
LRRC4 is also known as Brain tumor-associated protein BAG, Netrin-G2 ligand (NGL-2), Nasopharyngeal carcinoma-associated gene 14 protein (NAG14), which contains 1 Ig-like (immunoglobulin-like) domain and 9 LRR (leucine-rich) repeats, 1 LRRCT domain, 1 LRRNT domain.
LRRC4 / NGL-2 specifically expressed in brain.
LRRC4 / NGL-2 regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins.
LRRC4 / NGL-2 organize the lamina/pathway-specific differentiation of dendrites.
LRRC4 / NGL-2 plays a important role for auditory synaptic responses and involved in the suppression of glioma.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 55.8 kDa.
The protein migrates as 90-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human LRRC4, His Tag (LR4-H5221) is expressed from human 293 cells (HEK293). It contains AA Ala 39 - Lys 527 (Accession # AAI11562.1).
