Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses.
CD8A forms disulfide-linked heterodimers with CD8B at the cell surface.
CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
Additionally, CD8B plays a critical role in thymic selection of CD8+ T-cells.
A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched.
特徴
Human CD8A&CD8B Heterodimer Protein, His Tag&Tag Free, produced by co-expression of CD8 alpha and CD8 beta, has a calculated MW of 19.5 kDa (CD8 alpha) and 22.1 kDa (CD8 beta).
Subunit CD8 alpha is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit CD8 beta contains no tag but a basic tail at the C-terminus.
As a result of glycosylation, the heterodimer protein migrates as 30-32 kDa and 32-34 kDa under reducing (R) condition, and 30-33 kDa and 58-70 kDa under non-reducing (NR) condition (SDS-PAGE).
仕様
容量：1mg
Source：Human CD8A&CD8B Heterodimer Protein, His Tag&Tag Free (CDA-H52W5) is expressed from human 293 cells (HEK293). It contains AA Ser 22 - Asp 182 (CD8A) & Leu 22 - Pro 170 (CD8B) (Accession # P01732-1 (CD8A) & P10966-1 (CD8B) ).
Species Reactivity：Human
Host：HEK293
Tag：C-10×His | Native
Exp Region：Ser 22 - Asp 182 (CD8A) & Leu 22 - Pro 170 (CD8B)
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P01732-1 (CD8A) & P10966-1 (CD8B)
Protein ID：NP_001759.3 (CD8A) | NP_004922.1 (CD8B)
